{"id":203,"date":"2018-12-15T21:24:32","date_gmt":"2018-12-15T21:24:32","guid":{"rendered":"https:\/\/www.halocures.com\/?p=203"},"modified":"2022-05-26T18:06:44","modified_gmt":"2022-05-26T18:06:44","slug":"slowing-cerebral-palsy-with-a-cancer-drug","status":"publish","type":"post","link":"https:\/\/www.halo.science\/blog\/slowing-cerebral-palsy-with-a-cancer-drug\/","title":{"rendered":"Treating cerebral palsy with a repurposed cancer drug"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.halocures.com\/diseases\/cerebral-palsy\">Cerebral palsy<\/a>&nbsp;is the most common movement disorder in the United States, affecting 10,000 babies born every year. <a href=\"https:\/\/www.sralab.org\/researchers\/andrea-domenighetti-phd\">Andrea Domenighetti<\/a>, a research scientist at <a href=\"https:\/\/www.sralab.org\/\">Shirley Ryan AbilityLab<\/a>, has discovered that&nbsp;an <a href=\"https:\/\/www.sralab.org\/articles\/blog\/cancer-drug-shows-promise-treatment-cerebral-palsy\">FDA-approved drug used to treat blood cancers<\/a>&nbsp;shows promise for treating muscle contractures in cerebral palsy, and in April published his findings in<em>&nbsp;<\/em><a href=\"https:\/\/www.physiology.org\/doi\/prev\/20180425-aop\/abs\/10.1152\/ajpcell.00351.2017\">American Journal of Physiology-Cell Physiology<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Now at a crossroads, Dr. Domenighetti has laid out a detailed plan to shepherd his research into clinical trials (summary below), and is looking for partners to make it a reality.&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Are you an<strong> industry partner<\/strong> that can provide translational research expertise or other in-kind resources?&nbsp;<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Are you an <strong>impact investor<\/strong> who wants to help children with cerebral palsy?&nbsp;<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Are you a <strong>patient or patient advocacy group <\/strong>who can help spread awareness?<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Provide your information below to connect with Dr. Domenighetti.<\/p>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wpforms-container wpforms-container-full\" id=\"wpforms-698\"><form id=\"wpforms-form-698\" class=\"wpforms-validate wpforms-form\" data-formid=\"698\" method=\"post\" enctype=\"multipart\/form-data\" action=\"\/blog\/wp-json\/wp\/v2\/posts\/203\" data-token=\"2f8131c57ac702ce76709d2651193a61\"><div class=\"wpforms-head-container\"><div class=\"wpforms-title\">Support Cerebral Palsy Research<\/div><div class=\"wpforms-description\">Learn more about Dr. Domenighetti's breakthrough and how you can help bring it to patients<\/div><\/div><noscript class=\"wpforms-error-noscript\">Please enable JavaScript in your browser to complete this form.<\/noscript><div class=\"wpforms-field-container\"><div id=\"wpforms-698-field_0-container\" class=\"wpforms-field wpforms-field-name\" data-field-id=\"0\"><label class=\"wpforms-field-label\" for=\"wpforms-698-field_0\">Name<\/label><div class=\"wpforms-field-row wpforms-field-medium\"><div class=\"wpforms-field-row-block wpforms-first wpforms-one-half\"><input type=\"text\" id=\"wpforms-698-field_0\" class=\"wpforms-field-name-first\" name=\"wpforms[fields][0][first]\" ><label for=\"wpforms-698-field_0\" class=\"wpforms-field-sublabel after \">First<\/label><\/div><div class=\"wpforms-field-row-block wpforms-one-half\"><input type=\"text\" id=\"wpforms-698-field_0-last\" class=\"wpforms-field-name-last\" name=\"wpforms[fields][0][last]\" ><label for=\"wpforms-698-field_0-last\" class=\"wpforms-field-sublabel after \">Last<\/label><\/div><\/div><\/div><div id=\"wpforms-698-field_1-container\" class=\"wpforms-field wpforms-field-email\" data-field-id=\"1\"><label class=\"wpforms-field-label\" for=\"wpforms-698-field_1\">Email <span class=\"wpforms-required-label\">*<\/span><\/label><input type=\"email\" id=\"wpforms-698-field_1\" class=\"wpforms-field-medium wpforms-field-required\" name=\"wpforms[fields][1]\" required><\/div><div id=\"wpforms-698-field_2-container\" class=\"wpforms-field wpforms-field-textarea\" data-field-id=\"2\"><label class=\"wpforms-field-label\" for=\"wpforms-698-field_2\">Comment or Message <span class=\"wpforms-required-label\">*<\/span><\/label><textarea id=\"wpforms-698-field_2\" class=\"wpforms-field-medium wpforms-field-required\" name=\"wpforms[fields][2]\" required><\/textarea><\/div><\/div><div class=\"wpforms-field wpforms-field-hp\"><label for=\"wpforms-698-field-hp\" class=\"wpforms-field-label\">Phone<\/label><input type=\"text\" name=\"wpforms[hp]\" id=\"wpforms-698-field-hp\" class=\"wpforms-field-medium\"><\/div><div class=\"wpforms-submit-container\"><input type=\"hidden\" name=\"wpforms[id]\" value=\"698\"><input type=\"hidden\" name=\"wpforms[author]\" value=\"2\"><button type=\"submit\" name=\"wpforms[submit]\" id=\"wpforms-submit-698\" class=\"wpforms-submit\" data-alt-text=\"Sending...\" data-submit-text=\"Submit\" aria-live=\"assertive\" value=\"wpforms-submit\">Submit<\/button><\/div><\/form><\/div>  <!-- .wpforms-container -->\n\n\n<div style=\"height:38px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size wp-block-paragraph\"><strong>Abridged Research Proposal<\/strong><\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\t\t\t\t\t\t\t<strong>Milestone 1: <\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Goal: <\/strong>Evaluate effects of drug on contractured muscle tissue from children with cerebral palsy<\/li><li><strong>Timeline: <\/strong>2 Years<\/li><li><strong>Funding Needed&nbsp;<\/strong> $400,000<\/li><\/ul>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\t\t\t\t\t\t\t<strong>Milestone 2: <\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Goal:<\/strong> Determine&nbsp;<em>in vivo <\/em>effect of drug on muscle satellite cells (MuSCs)\u2014 a population of resident stem cells indispensable for postnatal muscle development and repair<\/li><li><strong>Timeline:<\/strong> 1 Year<\/li><li><strong>Funding Needed: <\/strong>$200,000<\/li><\/ul>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\t\t\t\t\t\t\t<strong>Milestone 3: <\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Goal:<\/strong> Design a multimodal rehabilitation strategy consisting of instrumented measurement of neuromuscular function in contractures subjected to the drug<\/li><li><strong>Timeline: <\/strong>1 Year<\/li><li><strong>Funding Needed: <\/strong>$200,000<\/li><\/ul>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Andrea Domenighetti at the Shirley Ryan AbilityLab discovered an FDA-approved cancer drug can slow muscle contractures in cerebral palsy. Now he&#8217;s at a crossroads. <\/p>\n","protected":false},"author":2,"featured_media":331,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"content-type":"","_mi_skip_tracking":false,"ngg_post_thumbnail":0,"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"categories":[283],"tags":[24,30,13,25],"class_list":["post-203","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","tag-cerebral-palsy","tag-featured","tag-heroes-of-medicine","tag-shirley-ryan-abilitylab"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Treating cerebral palsy with a repurposed cancer drug - Translation | Halo Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.halo.science\/blog\/slowing-cerebral-palsy-with-a-cancer-drug\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Treating cerebral palsy with a repurposed cancer drug - Translation | Halo Blog\" \/>\n<meta property=\"og:description\" content=\"Andrea Domenighetti at the Shirley Ryan AbilityLab discovered an FDA-approved cancer drug can slow muscle contractures in cerebral palsy. 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