Apiotix Technologies

Launched in 2020 as a spin-off from Hedera Ltd., Apiotix Technologies is a biotechnology company headquartered in Croatia that develops standardized bee-derived bio-actives. The company utilizes a patented, chemoselective extraction process—which avoids the use of aggressive solvents like alcohol—to produce a standardized phenolic acid polymer extract (PAPE) from propolis. This proprietary technology ensures consistent potency, purity, and a defined concentration of key bioactive components, such as p-coumaric acid, trans-ferulic acid, caffeic acid, and caffeic acid phenethyl ester (CAPE). By bridging nature and pharmaceutical science, the company offers multifunctional ingredients that serve as immunomodulators and antioxidants.

These standardized extracts are developed for integration into the pharmaceutical, cosmetic, veterinary, and functional food sectors, addressing global challenges such as antimicrobial resistance and skin aging. The company's PAPE extract has demonstrated significant clinical efficacy, including anti-wrinkle improvements comparable to retinol with high skin tolerance. Apiotix Technologies focuses on providing scientifically validated solutions, with its research-backed ingredients intended for large-scale production and commercial applications. The firm maintains a strong focus on pharmacology and chemistry, backed by a multidisciplinary team led by experts in veterinary pharmacology and gastroenterology.