Nanocrine Inc.

Nanocrine is a Frederick, Maryland-based biotechnology company that develops plasmonic imaging technology for the life sciences sector. The company's core platform utilizes proprietary, single-use plasmonic biosensor chips designed for integration with standard live-cell microscopes. This technology employs nanoscale geometric patterning to enable the label-free, real-time, and quantitative detection of molecular secretions from individual living cells. By combining the precision of surface plasmon resonance (SPR) with the spatial capabilities of conventional microscopy, the company's sensors allow researchers to visualize and map cell signaling, extracellular environments, and molecular concentration gradients as they occur.

This platform addresses critical limitations in traditional methods like ELISA or bulk assays, which typically provide only static snapshots of cellular activity. By enabling dynamic, real-time observation of cell-to-cell communication, the technology provides researchers with higher precision in studying complex biological processes, including tumor microenvironments, viral release dynamics, stem cell biology, and tissue repair. Nanocrine supports the biomedical research community through its specialized imaging chips and gold-coated glass surfaces, and it has engaged in collaborative research projects with organizations such as the National Cancer Institute and the National Institutes of Health to advance the understanding of disease biology and therapeutic responses.