Aaron Esser-Kahn is a Professor of Molecular Engineering at the University of Chicago's Pritzker School of Molecular Engineering, working at the intersection of chemistry, immunology, and materials science. In immunoengineering, he designs molecularly defined vaccine adjuvants, harnesses innate and trained immunity, and uses machine learning to discover immune modulators - work he is translating commercially as co-founder of Signl Bio. In materials science, he develops adaptive, force-responsive materials and energy-efficient polymer and carbon-capture systems. He also engineers nanomaterials and fluorescent-protein spin qubits for quantum biosensing in living cells, and builds computational models of viral evolution (Emergenet) to assess pandemic emergence risk.