Our laboratory employs modern synthetic organic chemistry, continuous directed molecular evolution, and protein design to develop innovative molecular technologies that report on or modulate key (bio)chemical regulators in living systems. Our approach is to build functional molecules, both small molecules, peptides, and entire enzymes, to solve problems in biomedical science. Currently, the group is focused on three primary project areas: Chemical biology approaches to interrogate signaling by protein chemical modifications; Activity-responsive RNA polymerases to analyze and control cell fate; Synthetic biology approaches to study and control the epitranscriptome.