Charles Gersbach
Principal Investigator
Duke University
I'm working on
8 months ago
Genome Engineering for Science and Medicine
About
Our research interests are in genome and epigenome editing, gene therapy, regenerative medicine, biomolecular and cellular engineering, synthetic biology, and genomics. Our work has led to new approaches to study genome structure and function, program cell biology, and treat disease.
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Duke University
CRISPR-mediated epigenetic reactivation therapy for Prader-Willi Syndrome
This innovative CRISPR-based therapy aims to reactivate silenced maternal genes in Prader-Willi Syndrome (PWS) by using dCas9 epigenome editors. The approach targets neuronal cells and has shown promising results in iPSC...
TechnologyConceptualUniversity
Duke University
CRISPRi-based gene silencing therapy for myotonic dystrophy
A novel CRISPRi-based therapy utilizing compact Cas9 variants for precise gene silencing of DMPK in myotonic dystrophy, delivered via myo-tropic AAV vectors. This approach aims to reduce disease symptoms and improve pati...
TechnologyConceptualUniversity
Charles Gersbach
Principal Investigator
Duke UniversityWork experience
Top industry applications
Oncology & cancer therapeuticsRegenerative medicine
Open to opportunities in
BiotechnologyCell TherapyGene TherapyGeneticsGenomicsMolecular Biology
Last updated Feb 2026
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