Our Catalophore platform encodes protein binding cavities as 3D physicochemical point clouds and compares them across a proteome-scale structural database, independent of sequence or fold. This lets us find functional equivalents that sequence- and structure-alignment methods miss, and focus engineering on the residues that actually shape activity, selectivity, and stability. We work with industry on enzyme discovery and engineering, variant prioritisation ahead of library construction, off-target site prediction and computational toxicology, and target identification. Engagements run from defined benchmark cases to multi-year closed-loop programmes with pharma partners.