A targeted epigenetic approach to downregulate SNCA expression in dopaminergic neurons, aiming to reduce α-synuclein pathology and neurodegeneration in Parkinson's Disease. This method seeks to maintain physiological SNC...
A novel gene therapy targeting APOEe4 expression aims to reduce amyloid-β pathology, decrease neuroinflammation, and slow cognitive decline in Alzheimer's patients without detrimental effects of complete APOE elimination...