Synthesize-X is a computational protein design studio focused on the rational engineering of thermodynamically stable and functionally specific de novo structures. We provide high-fidelity blueprints for 'Lock and Key' and 'Induced Fit' enzymes by mastering hydrophobic-hydrophilic patterning and electrostatic charge distribution to ensure structural integrity. Our work centers on generating validated, low-energy configurations for complex challenges, such as cancer-diagnostic signaling scaffolds and high-affinity inhibitors for major allergens.