JB
Joseph Brown
Principal Investigator
University of Toronto
I'm working on
7 months ago
Building an autonomous medicinal chemistry platform for peptides/peptidomimetics integrating high-throughput synthesis, direct-to-biology assays (AS-MS), and AI/ML. Applications include antimicrobial discovery and permeability/stability optimization for intracellular targets.
I'm looking for
7 months ago
Industry partners for sponsored research and co-development: target-focused campaigns, permeability/stability optimization, and data generation. Open to codesign, benchmarking studies, and shared datasets. Flexible IP structure; interested in pharma, biotech, and platform collabs
About
I am a Assistant Professor at the University of Toronto and a Faculty Advisor at the Acceleration Consortium, developing self-driving laboratories for drug discovery. My work focuses on peptides and peptidomimetics, combining automated synthesis, affinity-selection mass spectrometry (AS-MS), and machine learning to enable rapid, closed-loop hit-to-lead optimization. I specialize in multi-objective optimization of potency, selectivity, permeability, and stability, particularly for challenging targets such as Gram-negative bacterial outer membrane proteins. My group builds scalable, data-rich workflows that reduce cycle time and increase design quality, generating datasets and preclinical candidates
Partnering listings
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JB
Joseph Brown
Principal Investigator
University of Toronto
Work experience
Top industry applications
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Analytical ChemistryAntimicrobialsArtificial IntelligenceBiochemical EngineeringBiomimeticsChemistry
Last updated Mar 2026
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