JR
Joseph Rosenecker
Principal Investigator
Klinikum Ludwig Maximilians Universität München
I'm working on
10 months ago
Gene therapy, nucleic acid therapeutics, pulmonary delivery
About
Focus on nonviral vectors for nucleic acid therapeutics: engineering nanoparticles and polymer/peptide carriers for mRNA/DNA, optimizing magnetic and aerosol lung targeting, and characterizing airway biofluid interactions to improve transfection and translation to respiratory therapies.
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Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
Nature biotechnology 29 (2), 154-157, 2011
The magnetofection method: using magnetic force to enhance gene delivery
Walter de Gruyter 384 (5), 737-747, 2003
Targeted delivery of magnetic aerosol droplets to the lung
Nature nanotechnology 2 (8), 495-499, 2007
Enhancing and targeting nucleic acid delivery by magnetic force
Expert opinion on biological therapy 3 (5), 745-758, 2003
Insights into the mechanism of magnetofection using PEI‐based magnetofectins for gene transfer
The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2004
Current prospects for mRNA gene delivery
European Journal of Pharmaceutics and Biopharmaceutics 71 (3), 484-489, 2009
Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells
Journal of Biological Chemistry 278 (13), 11411-11418, 2003
Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei
The Journal of cell biology 166 (6), 815-825, 2004
In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers
The journal of gene medicine 2 (4), 269-278, 2000
Application of Novel Solid Lipid Nanoparticle (SLN)-Gene Vector Formulations Based on a Dimeric HIV-1 TAT-Peptide in Vitro and in Vivo
Pharmaceutical research 21, 1662-1669, 2004
Gene delivery to respiratory epithelial cells by magnetofection
The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2004
PEGylation improves nanoparticle formation and transfection efficiency of messenger RNA
Pharmaceutical research 28, 2223-2232, 2011
Interaction of liposomal and polycationic transfection complexes with pulmonary surfactant
The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 1999
Gene and cell therapy for cystic fibrosis: from bench to bedside
Journal of Cystic Fibrosis 10, S114-S128, 2011
Interaction of bronchoalveolar lavage fluid with polyplexes and lipoplexes: analysing the role of proteins and glycoproteins
The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2003
Diabetes mellitus in patients with cystic fibrosis: the impact of diabetes mellitus on pulmonary function and clinical outcome.
European journal of medical research 6 (8), 345-350, 2001
Genetic determination of diabetes mellitus in patients with cystic fibrosis
The Journal of pediatrics 127 (3), 441-443, 1995
Nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine
Biochimica et Biophysica Acta (BBA)-General Subjects 1573 (1), 75-83, 2002
Methodological optimization of polyethylenimine (PEI)‐based gene delivery to the lungs of mice via aerosol application
The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2005
Aerosolized nanogram quantities of plasmid DNA mediate highly efficient gene delivery to mouse airway epithelium
Molecular Therapy 12 (3), 493-501, 2005
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