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PW
Phillip West
Associate Professor
The Jackson Laboratory
Publications
20
Funding
0
Patents
0
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
Nature 472 (7344), 476-480, 2011
NF-κB and the immune response
Oncogene 25 (51), 6758-6780, 2006
Mitochondrial DNA stress primes the antiviral innate immune response
Biophysical Journal 108 (2), 3a, 2015
Mitochondria in innate immune responses
Nature Reviews Immunology 11 (6), 389-402, 2011
Recognition and signaling by toll-like receptors
Annu. Rev. Cell Dev. Biol. 22, 409-437, 2006
Mitochondrial DNA in innate immune responses and inflammatory pathology
Nature Reviews Immunology 17 (6), 363-375, 2017
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA
Cell 159 (7), 1563-1577, 2014
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1
Nature 569 (7758), 718-722, 2019
Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes
The Journal of Immunology 170 (12), 6217-6223, 2003
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Nature medicine 24 (1), 50-61, 2018
IκBβ acts to inhibit and activate gene expression during the inflammatory response
Nature 466 (7310), 1115-1119, 2010
Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin
Journal of Biological Chemistry 278 (26), 23624-23629, 2003
The molecular basis of tight nuclear tethering and inactivation of cGAS
Nature 587 (7835), 673-677, 2020
Mitochondrial dysfunction as a trigger of innate immune responses and inflammation
Toxicology 391, 54-63, 2017
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
Elife 8, e51031, 2019
Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL
The journal of immunology 184 (2), 956-964, 2010
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis
Cell 185 (17), 3214-3231. e23, 2022
Mitochondrial DNA stress signalling protects the nuclear genome
Nature metabolism 1 (12), 1209-1218, 2019
MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury
American Journal of Physiology-Lung Cellular and Molecular Physiology 306 (7 …, 2014
SnapShot: NF-κB signaling pathways
Cell 127 (6), 1286. e1-1286. e2, 2006
PW
Phillip West
Associate Professor
The Jackson Laboratory
Work experience
The Jackson Laboratory
Associate Professor
The Jackson Laboratory
Top industry applications
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Results may appear later and can be imperfect.
Open to opportunities in
Aging
Cell Biology
Genetics
Immunology
Intracellular Signalling
Intracellular Trafficking
Last updated Jun 2024
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