Rajarajan Amirthalingam Thandavarayan's profile

Rajarajan Amirthalingam Thandavarayan

Principal Investigator

Houston Methodist

I'm working on

8 months ago

Cardiometabolic biology, RNA processing, inflammation therapeutics

About

Studies cardiometabolic disease mechanisms across inflammation, oxidative/ER stress and fibrosis. Focus on RNA regulation (microRNAs, alternative polyadenylation) in heart failure and diabetes. Tests modulators and nano‑delivery toward translation.

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Houston Methodist

Aav9-mediated RNA interference targeting CSTF64 for heart failure therapy

This innovative therapy utilizes AAV9-mediated RNA interference to inhibit CSTF64, aiming to reduce cardiac fibrosis and improve heart function. Preliminary studies suggest CSTF64 upregulation exacerbates fibrosis, while...

TechnologyIn developmentUniversity

Rajarajan Amirthalingam Thandavarayan

Principal Investigator

Houston Methodist

Work experience

Houston Methodist

Principal Investigator

Top industry applications

Cardiovascular health

Expertise

CardiovascularClinical PharmacologyImmunohistochemistryMolecular BiologyMolecular MedicineTranslational Science

Last updated Jan 2026