RG
Roberto Gramignoli
Principal Investigator
Karolinska Institute
I'm working on
7 months ago
Regenerative medicine: Cell-based approaches
About
Hepatocyte transplantation as an alternative to liver transplantation for patients with fulminant liver failure or congenital defects. We transplanted patients in US and Sweden. We study alternative sources, such as iPS or fetal and perinatal stem cells (AEC). We validated AEC and developed clinical
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Karolinska Institute
Crispr/cas9 gene therapy platform for inborn metabolic liver diseases using humanized models and 3D organoids
A preclinical gene therapy platform combining CRISPR/Cas9 gene editing with patient-derived 3D liver organoids and humanized mouse models to correct inborn metabolic liver disorders ex vivo and in vivo. Offers a less inv...
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Human amnion epithelial cells and secretome-based therapy to reverse fibrosis
Stem cell technology leveraging human amnion epithelial cells (AEC) and their secreted mediators to reverse fibrosis in organs including intestinal tissue. Combines intact cells with paracrine factors (extracellular vesi...
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