SC
Sergio Catz
Principal Investigator
Scripps Research Institute
I'm working on
9 months ago
Innate Immunology, Vesicle Trafficking and Autophagy
About
Research centers on how immune cells traffic, secrete and signal. Work defines checkpoints in neutrophil activation, extracellular vesicle–mediated antigen relay, and lysosome–autophagy crosstalk in cystinosis, informing small‑molecule strategies to modulate inflammation and restore cellular homeostasis.
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Scripps Research Institute
Neutrophil-specific exocytosis inhibitors for neuroinflammation in multiple sclerosis
Novel small-molecule inhibitors (Nexinhib) that selectively block neutrophil secretion to reduce CNS inflammation and demyelination in experimental autoimmune encephalomyelitis (EAE) and potentially multiple sclerosis (M...
TechnologyConceptualUniversity
Scripps Research Institute
Small-molecule binders of LAMP2A for monitoring lysosomal function in lysosomal storage disorders
A novel diagnostic strategy using small-molecule binders of the CMA receptor LAMP2A to monitor lysosomal function in lysosomal storage disorders (LSDs). This approach addresses a critical gap in LSD management by trackin...
TechnologyConceptualUniversity
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