Ph-correcting topical therapeutics for atopic dermatitis treatment

Overview

Atopic Dermatitis (eczema) is associated with elevated skin pH, which disrupts the acid mantle that protects barrier integrity and supports a healthy skin microbiome. Soteri Skin has developed patented topical formulations that mimic and restore the skin's natural acid mantle, correcting pH to address the root cause of barrier dysfunction rather than just managing symptoms. In clinical evaluations of symptomatic AD patients, 100% experienced significant improvements as assessed by dermatologists, and 60% achieved complete symptom resolution. The non-prescription approach offers a safe, accessible therapeutic option for chronic eczema sufferers.

Technical specifications

Key features:

• Topical formulations engineered to mimic the skin's natural acid mantle
• Restores and maintains optimal skin pH to repair barrier function
• Supports microbial health and microbiome equilibrium on the skin
• Promotes skin differentiation and renewal processes
• Non-prescription, non-steroidal treatment approach
• Patented technology platform developed by Soteri Skin

How it works:

The formulations deliver acid-mimetic compounds that correct elevated skin pH back to its natural acidic range. This acidic environment is essential for critical enzymatic reactions involved in barrier maintenance and supports the balance of beneficial skin microorganisms. By normalizing pH, the therapy addresses the underlying cause of atopic dermatitis rather than merely suppressing inflammation.

Technology readiness level

The technology has progressed through initial clinical evaluations demonstrating strong efficacy signals. Future validation plans include rigorous testing of formulation impact on skin differentiation, renewal, and microbiome equilibrium, as well as comprehensive placebo-controlled clinical trials to establish long-term benefits and safety. The product is positioned for further co-development and partnership to advance through regulatory and clinical milestones.