Novel compound for peptide cyclization and radiometal chelation
Potential for use in peptide-based theranostics Effective in invoking cyclization of peptides
Highlights
- Potential for use in peptide-based theranostics
- Effective in invoking cyclization of peptides
Opportunity
A research team from the University of Alberta led by Dr. Frank Wuest has synthesized a new compound for use in peptide cyclization and as a bifunctional chelating agent in the radiolabelling of peptides. Preliminary results using a model peptide indicate that said compound is effective in peptide cyclization by selectively reacting with cysteine residues. A metal-binding DOTAGA moiety in the compound mediates its chelating properties. To facilitate radiolabeling, the compound readily forms stable complexes with metals, including Cu, Dy, Er, Ga, Gd, In, La, Lu, Sc, and Y. As proof-of-concept, the functionality of our compound has been demonstrated using octreotide as the peptide of choice, but may be applied to all cyclic peptides containing a disulphide bridge.
Competitive advantage
- Can be synthesized from commercially available reagents
- Cyclic peptide can be easily purified as the yields are high
- Can be used in the cyclization of peptides containing multiple cysteines irrespective of length and
- amino acid composition
Status
- Patented Pending
About University of Alberta
The University of Alberta is a large, comprehensive public research university in Edmonton with multiple campuses and a strong applied research culture. Industry engages through co-located labs and pilot-scale facilities, as well as established co-op and internship programs that place talent with partners year-round. Integration with Alberta’s province-wide hospital system supports clinical research and accelerates translation. Companies also benefit from proximity to regional industry clusters and collaboration hubs on and near campus for joint R&D and prototyping. Supported by NSERC, CIHR, SSHRC, and Canada Foundation for Innovation funding—plus provincial and industry support—the tech transfer office manages IP, licensing, and startup formation with streamlined sponsored-research agreements.
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