Lactic acid bacteria supernatant for candida biofilm removal
A novel lactic acid bacteria supernatant that effectively removes biofilm and reduces Candida cells in vulvovaginal candidiasis, maintaining microbiome balance. Seeking partnerships for formulation into creams or antifungal combinations for human trials.
Overview
This innovative solution utilizes a cell-free supernatant from a specific lactic acid bacteria strain to target and remove biofilm associated with Candida infections in vulvovaginal candidiasis. The approach reduces Candida cells to a minimal number, preserving them in yeast form, which is crucial for maintaining the balance of the vaginal microbiome and preventing dysbiosis such as bacterial vaginosis. Unlike complete eradication methods, this technique minimizes disruption to the natural microbial environment, offering a more sustainable and health-conscious solution.
Technical specifications
- Biofilm Removal: The supernatant effectively disrupts and removes biofilms formed by Candida species.
- Microbiome Preservation: By maintaining Candida in yeast form, the solution helps prevent dysbiosis.
- Additional Compounds: Contains beneficial compounds for host cells, enhancing overall vaginal health.
- Formulation Potential: Can be developed into standalone creams or combined with antifungals like clotrimazole for enhanced efficacy.
Technology readiness level
Currently at Technology Readiness Level 6, the solution has been validated in a vulvovaginal candidiasis mice model. Plans are underway to begin human trials, which will further evaluate its efficacy and safety in product formulations such as creams or as an adjunct to antifungal treatments.
About Universiti Putra Malaysia
Universiti Putra Malaysia (UPM) is a comprehensive public research university in Serdang, Greater Kuala Lumpur, with a campus that integrates classroom, laboratory, and field-testing environments. Companies engage through co-located labs, on-campus testbeds, and university-run farms that enable prototyping and trials close to production supply chains. Health system integration and proximity to Putrajaya’s ministries and the Cyberjaya tech corridor facilitate collaboration and timely access to partners. Research is supported by competitive funding from Malaysia’s Ministry of Higher Education, the Ministry of Science, Technology and Innovation, and international sponsors. A dedicated technology transfer office manages IP, licensing, and startup support, connecting companies with faculty expertise and specialized facilities.
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