Bioinspired microneedle patch for burn wound healing
A multifunctional microneedle patch designed to enhance burn wound healing by combining collagen scaffolds with pro-angiogenic and antibacterial properties. It accelerates healing processes like vascularization and collagen deposition, while offering antimicrobial protection.
Overview
The bioinspired multifunctional microneedle patch is an innovative solution targeting the complex challenge of deep burn wound healing. It leverages a combination of collagen-based materials and advanced therapeutic agents to accelerate wound closure, re-epithelialization, vascularization, and collagen deposition. By facilitating spatiotemporal therapeutic specificity, this patch is designed to address multiple stages of the wound healing process, ultimately promoting effective skin restoration.
Technical specifications
Key features:
- Microneedle tip: Composed of collagen scaffolds integrated with the pro-angiogenic molecule LXW7-DS-SILY (LDS) to promote rapid adhesion to deep tissue and encourage angiogenesis.
- Middle layer: A collagen matrix simulating the extracellular matrix to support tissue repair and cell migration.
- Outer layer: A flexible GelMa-based electrospun membrane infused with silver ions for long-term antimicrobial protection and enhanced oxygen exchange.
- Functional capabilities: Photothermal and antioxidative properties help reduce inflammation and support the healing process.
Technology readiness level
Currently at Technology Readiness Level 3, this microneedle patch has been developed and characterized in a lab setting. Future validations include in vitro and in vivo testing to assess its efficacy in promoting endothelial cell activities and controlling infection in deep burn wounds, as well as histological analyses to evaluate its impact on dermal repair and skin regeneration.
About University of California, Davis
UC Davis is a comprehensive public research university in Northern California, combining a land-grant heritage with an integrated academic health system and a veterinary teaching hospital. Industry engages through co-located clinical and translational facilities in Sacramento, a campus-adjacent research park, pilot-scale food and bioprocessing facilities, and a statewide extension network for field-to-market deployment. Proximity to the Bay Area and California's Central Valley enables rapid collaboration with startups and established enterprises, while corporate relations staff streamline access to faculty, talent, and core labs. Research is supported by competitive federal funding from agencies such as NIH, NSF, USDA, and DOE. A dedicated technology transfer office and venture support programs provide IP management, licensing, and startup formation pathways for industry partnerships.
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