Biodegradable cationic lipid nanoparticles for cleansing products
Innovative biodegradable cationic lipid nanoparticles designed for efficient delivery of active ingredients in cleansing products. These nanoparticles offer high performance, scalability, and a path to commercialization, leveraging advancements in flow chemistry and nanoengineering.
Overview
This solution features biodegradable cationic lipid nanoparticles (LNPs) engineered for the efficient delivery of active ingredients in cleansing products. Originating from the success of LNP-based vaccines, these nanoparticles represent a scalable and cost-efficient delivery system. By focusing on biodegradable materials, this technology offers a sustainable alternative for the personal care industry, promising enhanced deposition and performance of active ingredients.
Technical specifications
Key features:
- Customizable lipid nanoparticle systems for cationic, anionic, or lipophilic payloads
- Highly tunable for precise control over size, charge, and release characteristics
- Developed using advanced flow chemistry and nanoengineering for monodispersity and biodegradability
- Capable of efficient deposition on both hydrophilic and hydrophobic surfaces
- Scalable production plans up to kilogram-scale
Technology readiness level
Currently at TRL 3, the technology has been synthesized and characterized in a laboratory setting. The next phases include scaling the top candidates, performing biodegradability testing, and integrating the nanoparticles into prototype formulations, aiming for kg-scale production within one year.
About Case Western Reserve University
Case Western Reserve University is a comprehensive private research university anchored in Cleveland’s University Circle with a high‑intensity research enterprise. Its campus is co‑located with major hospital systems, giving industry partners access to clinical collaborators, regulatory know‑how, and real‑world validation environments. A large open‑access makerspace, shared core facilities, and an engineering co‑op program connect companies to rapid prototyping, testing, and talent pipelines. Research is supported by competitive federal funding from agencies such as NIH, NSF, DOE, and DoD. A dedicated technology transfer office, working with corporate engagement and entrepreneurship programs, supports IP strategy, licensing, sponsored research, and startup formation.
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