Tailored amorphous multiparous materials for dental health
Introducing tailored amorphous multiparous (TAMP) materials designed for dental applications, these bioactive silicate glasses enhance dentin regeneration and reduce hypersensitivity through optimized nanopore and macropore structures.
Overview
Tailored amorphous multiparous (TAMP) materials represent a groundbreaking advancement in dental health, specifically targeting dentin regeneration and hypersensitivity reduction. These materials are bioactive silicate glasses with carefully designed interconnected nanopores (~10 nm) and macropores (100s of microns). The nanopores enhance protein adsorption and cell response, promoting cell attachment, proliferation, and differentiation critical for dentin regeneration. Larger macropores facilitate cell migration and nutrient transport, essential for effective dental treatments. TAMP materials have demonstrated significant potential in occluding dentine tubules, thereby controlling hypersensitivity.
Technical specifications
- Bioactive Glass Composition: Utilizes calcium silicate for effective pulp capping and dentin bridge formation.
- Pore Structure: Features interconnected nanopores (~10 nm) for superior cell interaction and macropores for enhanced nutrient transport.
- Clinical Evidence: Shown to preserve alveolar bone height and promote active bone remodeling in clinical trials.
- Application Method: Applied as a slurry to dentine, reacting within seconds to provide deep occlusion and hypersensitivity control.
- Customization Potential: Future enhancements may include fluorine and potassium for expanded dental applications.
Technology readiness level
The TAMP material is currently at TRL 5, indicating validation in relevant environments. Ongoing partnerships aim to translate this technology into consumer dental care products, ensuring it meets practical application standards and regulatory requirements.
About Lehigh University
Lehigh University is a private, mid-sized research university in Bethlehem, Pennsylvania focused on interdisciplinary, hands-on problem solving. A multi-campus footprint includes a research campus with co-located labs, instrumentation, and prototyping spaces for rapid iteration with industry. Corporate engagement staff streamline sponsored research, capstones, internships, and short courses, and an on-campus incubator links partners to startup pipelines. Proximity to New York City and Philadelphia enables collaboration with regional manufacturers, logistics leaders, and growth-stage firms. Faculty secure competitive federal funding from agencies such as the NSF and DOE, and a technology transfer office supports IP, licensing, and new venture formation.
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