Accelerated evolution platform for heat-stable probiotics in gummy supplements
Developing non-GMO probiotic strains with enhanced heat and moisture tolerance for use in gummy supplements. This platform uses accelerated evolution and high-throughput screening to create strains that survive gummy manufacturing and maintain efficacy during storage.
Overview
This innovative solution leverages accelerated evolution to create non-GMO probiotic strains with enhanced tolerance to the heat and moisture conditions typical in gummy supplement manufacturing. By employing food-grade mutagens such as UV and psoralen, we mimic natural selection processes to produce Lactobacillus and Bifidobacterium strains that maintain viability at temperatures exceeding 80°C, ensuring effective probiotic delivery without compromising the product's texture or taste.
Technical specifications
Key features:
- Accelerated Evolution: Utilizes non-GMO mutagenesis to enhance probiotic strain resilience against heat and osmotic stress.
- High-Throughput Screening: Automated systems enable screening of over 10,000 variants to identify strains with superior viability.
- Integration into Gummy Products: Validated strains can be seamlessly incorporated into conventional gelatin or pectin-based gummies, maintaining their efficacy through manufacturing and storage.
Mutagenesis Process:
- Application of UV and psoralen mutagens to induce genetic diversity.
- Selection of robust strains that withstand manufacturing stresses.
Technology readiness level
The platform is currently at Technology Readiness Level 2, where initial strain selection and characterization are underway. Further validation steps include advanced mutagenesis rounds and high-throughput screening, followed by integration into gummy matrices for viability testing during manufacturing and storage.
About AgResearch
AgResearch is a New Zealand government research organization focused on the agricultural sector; formerly an independent Crown Research Institute, since July 1, 2025 it has operated as a group within the Bioeconomy Science Institute. With major campuses co‑located at Lincoln University and near Massey University, and shared spaces with FoodHQ partners, industry teams can access specialized labs and collaborative project space. Company‑owned research farms nationwide enable field validation and scale‑up alongside commercial partners. Research is supported by New Zealand Government investment through MBIE programmes such as the Strategic Science Investment Fund and National Science Challenges, complemented by competitive grants and contract research. A dedicated commercialisation team manages IP, patents, licensing, and MVP development, and connects through national commercialisation networks.
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