Adhesive ketoconazole films for treating recurrent vaginal yeast infections
Innovative mucoadhesive films using ketoconazole aim to improve the retention and efficacy of antifungal treatments for recurrent vaginal yeast infections. The films promise enhanced therapeutic outcomes compared to traditional gels and creams.
Overview
This solution involves the development of mucoadhesive films that incorporate ketoconazole, an antifungal agent, to treat recurrent vaginal yeast infections. The films are designed to adhere to the vaginal mucosa, ensuring prolonged retention and effectiveness of the antifungal treatment. This approach aims to overcome the limitations of traditional gels and creams, providing a more reliable and long-lasting treatment option.
Technical specifications
The films are formulated using sodium alginate, a mucoadhesive polymer, and polyvinyl pyrrolidone, a film-forming polymer. Ketoconazole is integrated as the active antifungal agent. The research proposes to develop multiple formulations with varying polymer compositions to optimize the film's properties, such as thickness, weight uniformity, peelability, mechanical strength, and drug release rate. The antifungal efficacy will specifically target Candida albicans, with additional tests for biocompatibility.
Technology readiness level
The current stage of development is at Technology Readiness Level 2. The concept has been formulated, and preliminary research is planned to further develop and validate the films' efficacy and safety through comprehensive testing, including biocompatibility studies in mice.
About University of Lagos
University of Lagos is a comprehensive public research university serving one of Nigeria’s largest student populations and the broader Lagos metropolis. Industry collaborates through co-located laboratories and testing facilities, structured student placements, and campus innovation hubs that support rapid prototyping with company partners. A medical college integrated with a major teaching hospital enables clinical studies, and proximity to the Yaba tech corridor and Lagos’s port economy supports on‑site pilots and user testing. Research activity is supported by national programs and competitive international sponsors. An established technology transfer office manages IP and licensing, while consultancy units deliver fee‑for‑service projects.
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