Advanced DOSY NMR for quantifying early hydrolysis in organo-trialkoxysilane solutions

Overview

Molecular Titans Ltd presents an advanced solution harnessing the power of Diffusion Ordered Spectroscopy (DOSY) NMR to non-destructively quantify early hydrolysis in concentrated organo-trialkoxysilane solutions. This method excels in resolving species by diffusion, enabling clear distinction between unreacted silanes, partially hydrolyzed species, silanols, and early oligomers. This capability allows for sensitive detection of changes in mixture composition and molecular size, providing a rapid, non-destructive industrial solution for quantifying hydrolysis.

Technical specifications

This solution leverages established DOSY methods, which have been validated for analyzing evolving polymer systems, reaction intermediates, and subtle changes in aggregation behavior. DOSY NMR can resolve diffusion differences as small as 1%, making it ideal for monitoring early-stage hydrolysis and condensation in complex, concentrated mixtures. The method is designed for highly viscous mixtures, capable of analyzing systems with up to 80% weight solid or pure molten plastic at elevated temperatures (up to 120°C). It does not require deuterated solvents due to the use of NOESY peak suppression, which removes solvent effects and provides clearer analysis.

Technology readiness level

Currently at Technology Readiness Level 4, this method has been validated in laboratory settings for analyzing complex systems. Future developments will focus on linking diffusion measurements to rheological markers and industrial implementation for quality assurance and control in polymer manufacturing.