Calice Biotech

Ai-powered multiomics platform for detecting environmental fingerprint genes in plant breeding

Technology
Conceptual
Company

An AI-driven computational platform that integrates environmental, transcriptomic, and genomic data to identify fingerprint genes explaining plant tolerance to environmental factors. Enables more informed cultivar selection and accelerates breeding decisions for specific environments.

Overview

This solution is an AI-powered multiomics integrative biology platform designed to accelerate plant breeding by identifying environmental fingerprint genes. The platform analyzes how environmental factors such as temperature, rainfall, and light influence gene regulatory programs across plant ecotypes. By integrating environmental, transcriptomic, and genomic information, it provides breeders and agricultural companies with data-driven insights into which cultivars are best suited for specific environmental conditions. The initial Minimum Viable Product (MVP) is currently in the patenting phase, with an enhanced version under development that will incorporate additional data layers for amplified analytical capabilities.

Technical specifications

Key features:

  • Integrates publicly available environmental, transcriptomic, and genomic datasets for comprehensive multiomics analysis
  • Clusters environmental variables into 39 distinct environment groups based on shared characteristics such as rain, temperature, and light
  • Employs machine learning algorithms, including random forest models, to detect shared differentially expressed fingerprint genes linked to environmental tolerance
  • Validated using transcriptomic data from 659 A. thaliana ecotypes grown under standardized laboratory conditions
  • Provides a scalable framework for analyzing gene regulatory program changes across diverse genomic backgrounds and phenotypes

How it works:

The platform takes transcriptomic data from multiple plant ecotypes alongside corresponding environmental metadata. Machine learning models then identify gene expression patterns that correlate with specific environmental clusters, producing a set of fingerprint genes associated with tolerance to defined environmental conditions. These fingerprints serve as biomarkers to guide cultivar selection and breeding strategies.

Technology readiness level

The MVP is currently in the patenting phase, indicating the core technology has been validated through computational analysis of 659 A. thaliana ecotype transcriptomes. An enhanced version incorporating additional omics layers is actively under development. The platform is positioned for early-stage partnerships with breeding programs, agricultural companies, and research institutions seeking to leverage computational tools for cultivar-environment matching.


About Calice Biotech

Calice is an Argentine agtech company founded in 2022 that specializes in AI-powered computational infrastructure for agricultural research and development. The firm focuses on digitalizing agricultural innovation by integrating data science, bioinformatics, and systems biology to optimize breeding and product deployment. Calice maintains headquarters in Buenos Aires with commercial operations in the United States and presence in Brazil.

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