Animal models for testing therapeutic approaches in autoimmune vasculitis
Leverage our advanced rat model of autoimmune vasculitis to test new therapeutic compounds. This model mimics human disease conditions, offering valuable insights into renal and lung involvement.
Overview
Our rat model of autoantibody-associated vasculitis (AAV) offers a robust platform for testing new therapeutic interventions. This model is characterized by anti-neutrophil cytoplasmic antibodies (ANCA) with myeloperoxidase (MPO) as the key antigen, mirroring the human disease. This model accurately replicates the clinical conditions of AAV, including renal and pulmonary manifestations, providing an invaluable tool for preclinical studies.
Technical specifications
- Disease Replication: The model exhibits clinical features such as rapidly progressive glomerulonephritis and pulmonary capillaritis.
- Immune Activation: Mimics human immune response with both innate and adaptive immunity activation, including high levels of cytokines like IL-6, IL-8, IL-2, and IL-4.
- Versatile Readouts: Allows detailed analysis of renal function, histology, and inflammation through techniques like IHC, FACS, and ELISPOTs.
- Extension Potential: Opportunities to extend the model to mice, enhancing its application scope.
Technology readiness level
Our animal model is at Technology Readiness Level 5, indicating that it has been validated in relevant environments and is ready for further refinement and optimization in partnership with industry collaborators.
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