AURASILICA: bioactive silica scaffold for scalp longevity

Overview

AURASILICA represents a groundbreaking advancement in cosmetic science, offering a bioactive silica nanocomposite scaffold engineered to mimic the natural follicular extracellular matrix (ECM) microenvironment. This innovative platform is designed to simultaneously address six hallmarks of aging, including cellular senescence and mitochondrial dysfunction, through the controlled release of silicon ions. Its tri-modal pore architecture ensures sustained delivery and compatibility with topical formulations, paving the way for significant advancements in scalp health and longevity.

Technical specifications

Key features:

• Tri-modal pore architecture: Allows for micro, meso, and macro-scale pore integration, enhancing the controlled release of silicon ions.
• Bioactive signaling: Stimulates collagen synthesis and modulates key pathways such as Wnt/β-catenin, crucial for scalp and follicle health.
• Regulatory compliance: Utilizes bioactive silica with INCI precedent, ensuring a clear path for cosmetic approval in major markets.
• Computationally optimized degradation: Aligns with follicle cycling timelines for sustained bioactive delivery.
• Compatibility: Designed for use in aqueous and hydroalcoholic vehicles, with pH compatibility ranging from 4.0 to 6.5.

Technology readiness level

AURASILICA is currently at Technology Readiness Level 2, indicating that the concept has been computationally validated with plans for in vitro biological testing. The project is poised for further development through targeted research phases, aimed at achieving a fully integrated topical formulation and commercial scalability within 18–24 months.