Automated stereocontrolled assembly-line synthesis

Overview

The automated stereocontrolled assembly-line synthesis is a robotic platform-based method that enables the iterative, highly precise construction of complex organic molecules. By mimicking natural biosynthetic pathways, this technology allows for the automated formation of C(sp3)–C(sp3) bonds with exceptional stereochemical control and reproducibility. This approach significantly accelerates the production of advanced molecular building blocks and complex small molecules, providing a scalable, robust alternative to traditional manual synthetic routes.

Technical specifications

• Capability for iterative, multi-step carbon-carbon bond formation (including up to six sequential one-carbon homologations).
• High stereochemical fidelity and precision, enabling the synthesis of molecules with tailored shapes and specific stereochemistry.
• Fully automated platform based on a Chemspeed SWING workstation, capable of handling air- and moisture-sensitive reagents under inert conditions.
• Integrated capabilities for automated functional-group manipulations, purification (catch-and-release), and reaction optimization.
• Temperature control range from -70 °C to 120 °C, supporting a wide variety of synthetic protocols.
• Automated sampling and analytical integration, including off-line LC-MS and NMR compatibility for real-time monitoring and verification.

Technology readiness level

The technology is at TRL 7. It has been validated through published research studies, including the successful synthesis of complex natural products like (+)-kalkitoxin using a commercial robotic platform (Chemspeed). The system is operational within a research facility and has demonstrated reproducible, high-performance results in challenging synthetic scenarios.