Automated UPLC / LC-MS workflows for mycotoxin quantification

Technology
Conceptual
University

A robotic platform automates UPLC/LC-MS workflows for precise mycotoxin detection, eliminating manual errors and improving accuracy. Ideal for grain extract analysis, it integrates automated sample prep with HPLC/LC-MS systems to meet regulatory standards.

Overview

The automated UPLC/LC-MS analytical workflow is designed to revolutionize mycotoxin quantification in grain extracts. By addressing the manual bottlenecks typically found in sample preparation, this solution enhances precision and accuracy in detecting mycotoxins. The robotic platform automates dilutions, solid phase extraction, and cleanup methods, seamlessly integrating with UPLC or LC-MS systems. This innovation is particularly useful for laboratories seeking to meet stringent regulatory detection and quantification limits.

Technical specifications

Key features:

  • Automated sample preparation using a robotic platform to reduce manual errors
  • Integration with UPLC and LC-MS systems for advanced detection methods
  • Automated dilutions and solid phase extraction for pre-concentration and cleanup
  • Online hyphenation capabilities with HPLC or LC-MS systems
  • Compatible with state-of-the-art technologies such as triple quad, time of flight, orbitrap, and ion mobility mass spectrometers
Technology readiness level

This technology is currently at Technology Readiness Level 2 (TRL 2). The concept has been formulated, and future validation plans include consulting with industry partners, developing and interfacing automated protocols, and validating the method according to International Committee of Harmonization guidelines.


About University of Technology, Sydney

University of Technology Sydney (UTS) is a comprehensive public research university with a practice‑based ethos and strong industry engagement at the southern gateway of Sydney’s CBD. For corporate partners, co‑located infrastructure includes UTS Tech Lab in Botany for prototyping, testing and pilot‑scale work, the 360‑degree Data Arena for immersive visualisation, and ProtoSpace for advanced additive manufacturing; a GMP‑lite biologics facility supports training and translational bioprocessing. The city campus sits within the Tech Central innovation district, connecting companies to startups and skilled talent via co‑op and cadetship pipelines. Research is supported by competitive national funding, including the Australian Research Council and National Health and Medical Research Council. A dedicated commercialisation and IP function and the UTS Startups community help move ideas to market.

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