Betaine supplementation to enhance cycling performance and epigenetic adaptation
Exploring the impact of betaine supplementation on cycling performance and epigenetic changes. This study aims to improve performance and metabolic recovery by modulating gene expression through methylation in trained cyclists.
Overview
This research investigates the potential of betaine supplementation to enhance cycling performance and facilitate epigenetic adaptations in trained athletes. By administering 3 g/day of betaine compared to a placebo, the study aims to assess improvements in a 75-km cycling time trial and metabolic recovery. The focus is on how betaine influences epigenetic modifications through the one-carbon metabolism pathway, which may enhance exercise-induced gene transcription.
Technical specifications
The study employs a randomized, placebo-controlled, double-blind, crossover design involving 25 male and female cyclists. Participants will undergo two supplementation periods, each lasting two weeks, separated by a two-week washout period. Performance metrics such as heart rate, cycling speed, cadence, distance, power, and oxygen consumption will be continuously monitored during the trials. Blood samples will be analyzed for betaine-related metabolites and epigenetic changes, providing insights into the underlying molecular mechanisms.
Technology readiness level
This research is at Technology Readiness Level 3, indicating experimental proof of concept. Initial trials have demonstrated a link between betaine supplementation and improved cycling performance, with further validation planned to explore its effects on epigenetic modulation.
About Appalachian State University
Appalachian State University is a comprehensive public research institution in Boone, North Carolina, serving the High Country and the wider region. Industry partners engage through a developing Innovation District on the university’s Millennial Campus, designed to co-locate applied research space and collaboration areas, and powered by a next‑generation, low‑carbon energy system. App State also operates New River Light and Power, a university‑owned electric utility that provides a rare, utility‑scale living lab for grid modernization and community‑based pilots. Faculty pursue competitively funded research supported by agencies such as the National Science Foundation, alongside state and philanthropic sources. A dedicated Office of Research and Innovation streamlines sponsored programs, agreements and research protections, and supports technology transfer and commercialization.
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