Bioadhesive pelargonium oral gel for biofilm control and repair
A bioadhesive oral gel utilizing Pelargonium sidoides root extract for effective biofilm control and oral tissue repair. The gel matrix enhances deposition and retention, targeting periodontal pathogens while preserving beneficial microorganisms and supporting oral health.
Overview
Our innovative solution is a bioadhesive oral gel formulated with standardized Pelargonium sidoides root extract, aiming to provide long-lasting biofilm control and support for oral tissue repair. Unlike traditional oral care products, this gel effectively adheres to gingival surfaces and periodontal pockets, ensuring prolonged local exposure and sustained activity of active ingredients. The gel acts selectively on periodontal pathogens, helping maintain a balanced oral microbiota and improving overall oral health. Clinical trials have demonstrated significant improvements in gingival adhesion, reduced bleeding on probing, and decreased periodontal pocket depth over 30 days.
Technical specifications
The bioadhesive gel is based on a thermosensitive matrix that transitions into an in situ gel upon application, enhancing its adhesion to oral tissues. This innovative formulation addresses the common challenge of rapid clearance by saliva and mechanical disruption. The standardised Pelargonium sidoides root extract offers selective antimicrobial action, targeting harmful oral pathogens while preserving beneficial microorganisms. The gel is part of a broader Pelargonium-based oral care system that includes mouth rinse and toothpaste, designed to provide comprehensive biofilm control and oral surface protection.
Technology readiness level
Currently at Technology Readiness Level 2, this solution is in the early stages of development. Sponsored research is aimed at further optimizing the thermosensitive gel formulation and harmonizing the accompanying mouth rinse and toothpaste. Future studies will focus on comparing this Pelargonium system with standard fluoride-based care to validate its efficacy, safety, and user acceptance in adults with gingivitis and early periodontitis.
About RamaZottius Lab
RamaZottius Lab is a Lithuanian medtech startup specializing in the development of innovative solutions for periodontal disease. The company's flagship product, Periozip, is a specialized gel featuring an advanced smart biomaterial of natural plant origin. Designed for application via a prefilled syringe directly into periodontal pockets, the product aims to harden within the cavity to inhibit the viability of disease-causing microorganisms. By providing a non-invasive alternative to traditional surgical interventions, the technology seeks to facilitate the repair of periodontal tissues while reducing the need for antibiotics and associated surgical risks.
Since its founding in 2020, the company has combined pharmaceutical biotechnology expertise with entrepreneurial leadership to address clinical needs in dental health. Supported by various European health innovation grants and clinical trials, the company is focused on securing CE certification for Periozip as a Class IIa medical device and scaling its commercialization through licensing and strategic partnerships. RamaZottius Lab aims to improve patient outcomes by offering safer, non-invasive treatment options that protect gums and prevent tooth loss, positioning itself within the deep-tech ecosystem to expand its international reach.
Inquire about this partnering listing
Looking for
Industry applications
delivered to your inbox.