Biocatalytic mono-hydroxylation for crop protection

Overview

Biocatalysis provides an approach for producing mono-hydroxylated compounds used in crop protection. Using enzymes such as oxygenases and peroxygenases, the technology enables selective hydroxyl-group introduction under mild conditions, supporting environmental sustainability. The method aligns with green chemistry principles by offering a cleaner alternative to conventional synthetic routes that rely on costly and scarce metal catalysts.

Technical specifications

The biocatalytic process uses enzymes and microorganisms to perform C−H oxyfunctionalisation, a challenging transformation in organic chemistry. Operations are conducted under near-ambient conditions in an aqueous environment, leveraging enzyme systems and microorganisms from the CSIR library. Reported prior successes include the production of (-) Ambrox for fragrances, along with developments in bioplastics and natural pesticides, indicating versatility across application areas.

Technology readiness level

The technology is currently at TRL 2, validated on a laboratory scale. Future plans include scaling up the process to produce samples for testing, with potential for further scale-up toward commercial levels. Technology transfer activities are intended to support commercialization.