Bioconjugation crosslinker with hydrolytically cleavable acetal/ketal linkages
A novel bioconjugation crosslinker using hydrazine-benzaldehyde chemistry with hydrolytically cleavable acetal/ketal linkages, enabling degradable crosslinked materials in biocompatible environments. Tailored for drug delivery and biomedical applications.
Overview
This innovative bioconjugation technology leverages hydrazine-benzaldehyde chemistry to create crosslinkers with hydrolytically cleavable acetal or ketal linkages. These crosslinkers enable the formation of degradable materials under biocompatible conditions, offering significant potential in drug delivery and other biomedical applications. By integrating acetal/ketal functionalities, the technology allows for the precise tuning of degradation rates, making it suitable for applications where controlled release or material degradation is crucial.
Technical specifications
- Bioconjugation Chemistry: Utilizes hydrazine-benzaldehyde reactions, known for their biocompatibility and tunability.
- Degradable Linkages: Acetal/ketal linkages hydrolyze at adjustable rates under acidic or neutral conditions.
- Material Compatibility: Applicable to a wide range of biomacromolecules, polysaccharides, and proteins.
- Synthesis: Designed for simplicity and scalability using commercially available chemicals.
- Environmental Conditions: Functions at room temperature with the capability to adjust crosslinking kinetics using biocompatible catalysts.
Technology readiness level
The current development stage is at Technology Readiness Level 4, indicating that the technology has been validated in a laboratory environment and is ready for further development and optimization in more practical settings.
About Stanford University
Stanford University is a comprehensive private research university known for cross-disciplinary scholarship and an entrepreneurial culture. Industry engages through a long-standing research park that co-locates corporate R&D with university labs, plus corporate affiliates programs and sponsored research mechanisms. Integration with a major academic medical center enables clinical translation, while shared core facilities and prototyping spaces streamline collaboration. Research is supported by competitive federal funding from agencies such as NIH, NSF, DOE, and DARPA, alongside philanthropy and industry partnerships. A dedicated Office of Technology Licensing supports IP strategy, licensing, and startup formation.
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