Biodegradable block copolymer micelles for encapsulation of active ingredients
Innovative biodegradable block copolymer micelles for encapsulating and releasing active ingredients, featuring tunable biodegradability and enhanced environmental impact.
Overview
Researchers at the University of Waterloo have developed biodegradable block copolymer micelles designed for the encapsulation and controlled release of active ingredients. These micelles are synthesized using radical polymerization, incorporating biodegradable comonomers to enable environmental degradation. The technology offers a versatile solution for encapsulating both hydrophilic and hydrophobic substances, providing a controlled release mechanism while minimizing environmental impact.
Technical specifications
Key features:
- Utilizes controlled radical polymerization to create block copolymers.
- Incorporates thionolactones to introduce hydrolyzable thioesters for biodegradability.
- Capable of encapsulating a wide range of active ingredients.
- Characterized by dynamic light scattering and electron microscopy.
- Release kinetics measured using UV-Vis spectroscopy.
Applications:
- Pharmaceutical and nutraceutical delivery systems.
- Agrochemical formulations.
- Personal care and cosmetic products.
Technology readiness level
This technology is currently at TRL 3, having been experimentally demonstrated to a certain extent in a laboratory setting. The next steps involve further synthesis and characterization of the biodegradable polymers and micelles, followed by validation of biodegradability according to ISO protocol 17556:2012.
About University of Waterloo
University of Waterloo is a public research university in Ontario, Canada, known for an entrepreneurial, STEM‑driven culture. A globally recognized co‑op program places students with employers year‑round, creating direct talent pipelines and de‑risked pathways into sponsored research and contract development. An adjacent research and technology park hosts corporate R&D alongside faculty labs, and the campus sits within the Toronto–Waterloo innovation corridor for ready access to partners, investors, and scale‑up resources. Research is supported by competitive federal funding from Canada’s Tri‑Council agencies (NSERC, CIHR, SSHRC) and international programs. A creator‑owned IP policy and a dedicated tech transfer office enable flexible agreements, licensing, and spinouts.
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