Biodegradable micro-encapsulation technology using controlled co-precipitation
Innovative biodegradable micro-encapsulation method using shellac and oil-based active ingredients to create customizable core-shell nanocapsules. High encapsulation efficiency and tunable release make it ideal for various applications.
Overview
This biodegradable micro-encapsulation technology utilizes a novel controlled co-precipitation process to create hierarchical core-shell nanocapsules and microcapsules. Using shellac, a natural resin, and oil-based active ingredients, the process achieves high encapsulation efficiency of 98% and allows for tunable release of active ingredients for up to 50 days at room temperature. The method is cost-effective, requiring no complex equipment, and is easily scalable, making it suitable for diverse applications such as pharmaceuticals, agriculture, and cosmetics.
Technical specifications
- Materials: Shellac (biodegradable resin) and oil-based active ingredients such as capsanthin
- Process: Rapid mixing of vegetable oil and shellac leads to co-precipitation and formation of core-shell nanocapsules
- Customizability: Capsule size (average 200 nm) and shell thickness adjustable by altering polymer concentration and mixing speed
- Efficiency: 98% encapsulation efficiency with a highly tunable release period
- Scalability: Process does not require energy-intensive instruments
Technology readiness level
The technology is currently at TRL 4, having been validated in laboratory settings. Future plans include exploring alternative biodegradable polymers and scaling up to create microcapsules under 6 micrometers. The project aims to develop cost-effective formulations for various applications over the next 1 to 2 years.
About Harvard University
Harvard University is a comprehensive private research university in Cambridge and Boston, recognized for intensive, cross-disciplinary research and education. Industry engages through an integrated innovation ecosystem with shared core facilities, corporate-sponsored research, and incubator space in Allston. Affiliated teaching hospitals in the Longwood Medical Area enable clinical collaboration and translation, while proximity to Kendall Square places partners in a dense R&D corridor. Research is supported by major federal agencies such as the NIH, NSF, DOE and DARPA, as well as philanthropic and corporate sponsors. A dedicated technology transfer office manages IP, licensing, and startup formation and streamlines agreements for corporate collaborations.
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