Bioengineered peptide production platform via fermentation technology
A patented fermentation platform for producing functional peptides at gram-scale per liter. This host-independent technology utilizes engineered proteins with tandem repeats and purification tags to enhance yield and purity. Scalable for various industrial applications.
Overview
Biocatalist, LLC introduces a revolutionary bioengineered peptide production platform that leverages advanced fermentation technology to achieve gram-scale peptide production per liter of culture. This patented solution is designed to overcome existing limitations in peptide synthesis by using engineered proteins with tandem repeats and purification tags. The technology is host-independent, allowing for flexibility in selecting cost-effective hosts that can perform necessary post-translational modifications. This innovative approach ensures the production of high-yield, pure peptides suitable for diverse industrial applications.
Technical specifications
Key features:
- Patented fermentation process capable of producing over one gram per liter of functional peptides.
- Utilizes engineered proteins with tandem peptide repeats and spacer peptides to enhance yield.
- Incorporates a short purification tag for improved purification efficiency.
- Host-independent platform, adaptable for use with yeast and E. coli, enabling selection of the most effective production system.
- Chemo-enzymatic process ensures peptides are free of extraneous amino acids.
- Scalable to pilot and industrial levels using bioreactors.
Technology readiness level
The technology is currently at Technology Readiness Level 4 (TRL 4), indicating that it has been validated in a laboratory environment. Future validation plans include optimizing expression systems using both yeast and E. coli, and scaling up the production process in a five-liter bioreactor to establish the basis for larger scale operations.
About Biocatalist, LLC
Biocatalist is a biotechnology company that has developed a patented process using recombinant DNA technology for the manufacturing of peptides and peptide libraries. The company's platform engineers proteins containing repeated units of specific peptides, which are then expressed in host organisms and purified. This approach provides a sustainable alternative to traditional chemical synthesis, which is known to generate significant amounts of toxic waste. By enabling the biological production of shorter natural peptides, the technology is designed to reduce manufacturing costs by at least five-fold, decrease energy consumption, and shrink required bioreactor sizes by up to 10-fold.
The company’s solutions support ESG objectives for manufacturers in industries such as pharmaceuticals, medicine, and agriculture, including the production of peptide hormones, cancer vaccines, antimicrobial peptides, and bio-pesticides. Biocatalist offers custom services for peptide and peptide library production, as well as specialized mass spectrometry calibration standards. These offerings are designed to help customers improve production efficiency, reduce environmental impact, and achieve greater accuracy in analytical applications. Located in Torrance, California, the company emphasizes the intersection of technical innovation and environmental responsibility in its product and service delivery.
Inquire about this partnering listing
Looking for
Industry applications
delivered to your inbox.