Biofungicide neobai with optimized germacrene D production

Overview

NeoBai is an innovative biofungicide developed by Mycobai, utilizing the active compound germacrene D to effectively inhibit the fungus N. rosae. The biofungicide is crafted through a biotechnological process involving genetically modified Saccharomyces cerevisiae, which significantly enhances the yield of germacrene D to 7.9 grams per liter. This advancement addresses the limitations of traditional extraction methods, offering a sustainable and efficient solution for agricultural applications.

Technical specifications

Key features:

• Contains 6% germacrene D, formulated with 94% biodegradable adjuvants
• Effective inhibition of N. rosae at a concentration of 600 μg/ml
• Two applications per hectare, 7 days apart, using 4 liters in total
• Product remains effective for up to 2 years from manufacture

Production process:

• Genetic modification of S. cerevisiae enhances the mevalonate pathway, suppressing secondary pathways to boost germacrene D production
• Fermentation conditions optimized to achieve high yield
• Efficient extraction and purification methods developed to ensure product quality

Technology readiness level

Currently at TRL 2, this technology is in the early stages of development. The focus is on optimizing strain development, fermentation, and extraction processes, along with efficacy testing and regulatory compliance to advance readiness for agricultural applications.