Bioprospecting antiviral metabolites from sponge-associated microorganisms
Exploring sponge-associated microorganisms in the Red Sea to discover novel antiviral metabolites with unique scaffolds and mechanisms, utilizing expertise in natural products chemistry, metabolomics, and microbiology.
Overview
This innovative research project explores the potential of sponge-associated microorganisms from the Red Sea as a source for new antiviral drug candidates. By leveraging the rich phylogenetic diversity of these microorganisms, the project aims to discover and characterize novel antiviral metabolites with unique chemical scaffolds and mechanisms of action. This bioprospecting effort is a collaboration between experts in natural products chemistry, metabolomics, genomics, and microbiology from Egypt and Saudi Arabia, targeting viral infections which remain a significant global health challenge.
Technical specifications
The project involves several key steps:
- Characterization of microorganisms: Identification and description of novel bacterial and fungal strains associated with sponges and corals.
- Fermentation and extraction: Cultivation of these strains followed by extraction of their metabolites.
- Screening and isolation: Antiviral screening of extracts, isolation of active metabolites, and structure elucidation.
- In silico studies: Molecular docking studies to predict interactions between identified compounds and viral targets.
- Mechanism investigation: Exploring the antiviral mechanisms to understand how these compounds can inhibit viral infections.
Technology readiness level
The research is currently at Technology Readiness Level 4, indicating that the basic technology is validated in a laboratory environment. Further development and validation are planned to advance the technology towards commercial viability.
About Deraya University
Deraya University is a growing private institution in Upper Egypt serving New Minya and the surrounding region with an emphasis on applied learning and community impact. Co-located teaching and research labs, on-campus health clinics, and an applied sustainability center enable hands-on collaboration with external partners. Clinical links, including a training protocol with Baheya Hospital, provide real-world environments for translation and workforce development. Research activity is supported by competitive national programs and international collaborations. A dedicated continuing-education academy, delivered with recognized external organizations, offers professional upskilling and supports knowledge transfer.
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