Carbon dot-hydrogel platform for sustained and localized pain relief
A novel carbon dot-hydrogel platform designed for sustained and localized delivery of a pain-relieving drug. This system enhances skin permeability and adhesion, offering targeted relief with reduced systemic side effects.
Overview
The carbon dot-hydrogel platform offers a revolutionary approach for localized pain management. By capping a pain-relieving drug onto carbon dots derived from amino acids and integrating it into a skin-adhesive hydrogel, this solution enables targeted delivery directly to affected areas. The innovation lies in the near-zero dimension of the carbon dots, which promotes effective skin permeability, allowing the drug to penetrate the skin for sustained relief without the side effects associated with systemic administration.
Technical specifications
- Carbon Dots: Derived from amino acids, these near-zero dimension particles enhance permeability across the skin.
- Hydrogel Integration: Bioadhesive hydrogel ensures prolonged skin retention and slow drug release.
- Mechanism of Action: Targets γ-aminobutyric acid-B receptors to reduce excitatory neurotransmitter release and neuronal excitability, offering effective management of nerve pain.
- Localized Efficacy: Proven to relieve pain in specific areas with direct application, unlike traditional oral administration which impacts the entire body.
Technology readiness level
Currently at TRL 4, this technology has undergone preclinical studies demonstrating localized pain relief capabilities. Further collaboration is sought to enhance the TRL and explore additional applications.
About Siksha O Anusandhan University
Siksha ‘O’ Anusandhan is a large private deemed university in Bhubaneswar with a comprehensive, research-intensive professional profile. Its engineering and technology campus is complemented by the co-located Institute of Medical Sciences and SUM Hospital, creating an institutional pathway between academic research, clinical settings, and accredited diagnostic services. Corporate engagement is supported through industry agreements, joint training and research, internships, and partner-supported laboratories or centres of excellence. Research receives competitive support from agencies including the University Grants Commission, Department of Science and Technology, Department of Biotechnology, Indian Council of Medical Research, Indian Council of Agricultural Research, and Council of Scientific and Industrial Research. A university research and development function, patent activity, and technology-licensing relationships with India’s National Research Development Corporation support movement from invention toward external use.
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