Ceramide targeting to stratum corneum using cerosomes
Innovative use of Cerosomes to effectively deliver ceramides to the Stratum corneum, enhancing skin barrier function with potential applications in skincare and dermatology.
Overview
The proposed solution introduces a novel approach to enhance the delivery of ceramides (CER) to the Stratum corneum (SC) using Cerosomes (CERO). This innovation addresses the lack of effective carrier systems capable of targeting CER to the SC, which is crucial for maintaining its barrier function. By leveraging the potential of CERO, this research aims to optimize the delivery of the key lipids CER NP and CER AP in the SC, which are essential for skin health and integrity.
Technical specifications
Key features:
- Utilizes Cerosomes as nanocarriers for targeted ceramide delivery to the Stratum corneum.
- Incorporates advanced characterization techniques like Cryo-TEM, SEM, and X-ray for morphological analysis.
- Utilizes dynamic light scattering and optical microscopy for size and distribution analysis.
- Employs atomic force microscopy (AFM) for high-resolution morphology assessment.
- Evaluates penetration kinetics and diffusion behavior on human ex vivo skin using HPLC and deuterated CER.
Technology readiness level
Currently at TRL 3, this technology is in the experimental proof-of-concept stage. Future validation steps include comprehensive physical-chemical evaluations and penetration testing on human skin samples to assess efficacy in real-world applications.
About Universität Halle
Martin Luther University Halle‑Wittenberg is a comprehensive public research university based in Halle (Saale), Germany, combining long‑standing scholarship with a modern, collaborative research culture. Its natural sciences are embedded in the Weinberg Campus technology park, where university units, startups, and national research institutes share facilities and proximity, enabling rapid prototyping and scale‑up via on‑site incubator and accelerator programs. A central Transfer and Entrepreneurship Office supports IP management, licensing, and venture creation, providing a single entry point for corporate engagement. Research is supported by competitive funding from the German Research Foundation and federal ministries, alongside European Union programs. A mature regional innovation ecosystem in Central Germany makes it an efficient base for industry collaboration.
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