Chitosan-based biopolymer microbicides for treating vaginal yeast infections
This technology leverages chitosan's antifungal and biofilm-disrupting properties to enhance the efficacy of existing antifungal treatments for recurrent vaginal yeast infections, offering a potentially safer and more effective alternative.
Overview
This innovative solution centers on the use of chitosan-based biopolymers as adjuvants in the treatment of recurrent vaginal yeast infections (VYI) caused by Candida albicans. By utilizing chitosan's inherent antifungal properties and its ability to disrupt biofilms, this approach aims to enhance the effectiveness of current antifungal medications such as clotrimazole. The solution presents a potential to reduce the required dosage of antifungals, thereby minimizing the risk of developing antifungal resistance and offering a safer, more effective treatment option.
Technical specifications
Key features:
- Utilizes chitosan, known for its antifungal and biofilm disruption capabilities
- Formulations may include gels and suppositories for vaginal application
- Potentially synergistic with over-the-counter antifungals like clotrimazole
Research Phases:
- In-silico studies: Focus on chitosan's properties and explore suitable formulations
- In vitro testing: Evaluate efficacy against Candida albicans strains and biofilm disruption
- Stability testing: Use computational simulations to test formulation stability at vaginal pH
Technology readiness level
The technology is currently at TRL 3, indicating that it is in the early stages of experimental proof of concept, with ongoing in-silico and in vitro studies to validate its effectiveness and safety.
About R.V. College of Engineering
RV College of Engineering (RVCE) is an autonomous, self‑financing engineering institution in Bengaluru, affiliated to Visvesvaraya Technological University and accredited NAAC A+. It connects to industry through an active Industry Institute Interaction Cell, 150+ MoUs, and co‑located, industry‑sponsored labs and Centers of Excellence that enable joint training, prototyping, and upskilling on campus. Proximity to Bengaluru’s technology cluster supports internships, capstone co‑supervision, and consultancy engagements throughout the year. Research here is supported by competitive national programs and industry, including DRDO/NRB, AICTE, and ISRO collaborations. An IP Coordination Cell, together with incubation resources and a student‑run Entrepreneurship Development Cell, assists with patenting, licensing, and venture formation.
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