Cold-active postbiotic platform for oral microbiome modulation
A cold-active postbiotic platform derived from Lactobacillus fuchuensis H.Y.35, designed for incorporation into oral-care products like toothpaste and mouthwash. This solution targets oral microbiome modulation by using bioactive metabolites and peptides, offering antimicrobial, antioxidant, and wound-healing benefits without relying on harsh antimicrobials.
Overview
The cold-active postbiotic platform derived from Lactobacillus fuchuensis H.Y.35 is a novel solution designed to enhance oral microbiome health. It is incorporated into toothpaste, mouthwash, and other gum-health products to provide targeted modulation of the oral microbiome. Unlike traditional antimicrobials, this platform uses strain-specific bioactive metabolites to support microbial balance and suppress harmful pathogens. Its benefits include antioxidant, antimicrobial, wound-healing, and cryoprotective activities, which collectively aim to improve gingival health.
Technical specifications
The postbiotic platform is developed from cell-free extracts of Lactobacillus fuchuensis H.Y.35. It includes a range of bioactive compounds identified through advanced metabolomic and proteomic analyses. Key features include:
- Antioxidant and antimicrobial compounds: Phenolic acids, lipopeptide-like compounds, and antimicrobial peptides.
- Wound-healing capabilities: Promotes tissue repair and reduces oxidative stress.
- Compatibility and stability: Formulation compatibility and stability are ensured through freeze-drying and food-grade fermentation processes.
- Low cytotoxicity: Ensures compatibility with oral tissue.
Technology readiness level
The technology readiness level of this postbiotic platform is currently at TRL 4. It has demonstrated efficacy in vitro against key oral pathogens such as Porphyromonas gingivalis and Streptococcus mutans. Ongoing validation includes oxidative stress reduction, biofilm modulation, and pilot human studies to assess oral microbiome modulation and clinical outcomes.
About Humber Polytechnic
Humber Polytechnic is a large, multi-campus public polytechnic in Toronto, known for career-focused education and applied research. Industry collaboration is embedded through co-op and work-integrated learning pipelines, contract research, and co-located labs where partners prototype and validate alongside faculty and students. On-campus innovation hubs and industry-grade testbeds support prototyping, automation, and product usability testing, while dedicated partnership managers streamline scoping, IP, and timelines from intake to delivery. Applied research is backed by NSERC, Mitacs, and Ontario innovation programs, together with direct industry sponsorship. A centralized applied research and commercialization office supports IP protection, licensing, and pathways to venture creation.
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