Combiotic™: natural antimicrobial for fresh breath with biofilm disruption

Technology
Conceptual
Company

Combiotic™ is a natural antimicrobial platform combining plant-derived molecules and inorganic salts to selectively disrupt biofilms and neutralize volatile sulfur compounds, offering an effective and safe solution for fresh breath through oral care products.

Overview

Combiotic™ is an innovative antimicrobial platform designed to provide fresh breath by targeting and disrupting biofilms responsible for oral malodor. Unlike traditional solutions that merely mask odors, Combiotic™ uses a combination of plant-derived small molecules and inorganic salts to neutralize volatile sulfur compounds at their source. This non-antibiotic, alcohol-free platform is scalable and suitable for daily consumer use, ensuring extended freshness through controlled-release formulations available in hydrogel, spray, and rinse forms.

Technical specifications

Key features:

  • Biofilm Disruption: Effectively targets bacterial membranes and extracellular polymeric substances (EPS) to rapidly reduce odor-producing anaerobes.
  • Delivery Forms: Available in hydrogel, spray, and low-foaming rinse formulations for sustained activity and extended freshness.
  • Safety Profile: Strong tissue compatibility confirmed by third-party GLP ISO 10993 biocompatibility testing.
  • Scalability: Designed for easy scale-up, leveraging food-grade polymers for controlled release.
Technology readiness level

The technology is currently at TRL 2, having demonstrated functionality in controlled environments. We are seeking partnerships for further development and market deployment, focusing on consumer formulation optimization, sensory validation, and regulatory alignment.


About COMBio

A spin-off from a computational biodiscovery research center (COMBio) at AIMST University in Malaysia. Founded by a team of microbiologists and bioinformaticians, it focuses on phage technology to reduce agricultural and food losses.

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