Continuous organic acid recovery using semi-partition bioreactors
Semi-partition bioreactors (SPB) offer a novel approach for continuous organic acid production and recovery, enhancing yield and purity through in-situ liquid-liquid extraction. This innovative system reduces product inhibition and material costs, facilitating scalable and sustainable production.
Overview
The semi-partition bioreactor (SPB) represents a cutting-edge solution for the continuous production and recovery of organic acids. By integrating fermentation and in-situ separation through liquid-liquid extraction, the SPB addresses common challenges in traditional bioreactors such as product inhibition and extensive downstream purification. This innovative system enhances yield and purity of the target biomolecules, making organic acid production more sustainable and economically viable for large-scale applications.
Technical specifications
Key features:
- In-situ separation: Real-time recovery of organic acids directly during fermentation, reducing inhibitory effects of accumulated products.
- Liquid-liquid extraction: Utilizes partitioning behavior of solvents to selectively separate and recover target molecules, improving product purity.
- Scalability: Demonstrated efficacy at 1L scale with plans to scale up to 5L, supporting continuous production and recovery.
- Cost efficiency: Reduces material costs through solvent reuse and minimizes purification expenses.
Technology readiness level
The semi-partition bioreactor technology is currently at TRL 5, having been validated in a laboratory environment for lactic acid production. Further research and development are underway to expand its application to other organic acids and scale up the process for broader industrial use.
About Stellenbosch University
Stellenbosch University is a comprehensive public research university in South Africa’s Western Cape with a strong research culture. Industry collaboration runs through Innovus, the university’s technology transfer office, and SU LaunchLab, which incubates spinouts and partner ventures. Field-scale testing uses university experimental farms at Welgevallen and Mariendahl, and clinical translation is supported by the Biomedical Research Institute on the Tygerberg medical campus alongside the teaching hospital. Research is backed by competitive national funding, including the National Research Foundation and the South African Medical Research Council. Innovus manages IP, licensing, and company formation to streamline engagement.
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