Covalent protein films using computational design and co-polymerization
Innovative covalent protein films engineered using machine learning tools for protein design, forming tough, biodegradable films upon mixing. Applications in moisture barriers and robust coatings.
Overview
Covalent protein films represent a cutting-edge solution in biomaterial engineering, leveraging advanced machine learning technologies for protein design. These films are engineered by mixing two types of protein building blocks, each stable and soluble on its own, to form a tough, covalently crosslinked network. This innovative approach allows for the creation of films with tunable properties, including biodegradability, making them suitable for various applications such as moisture barriers and robust coatings.
Technical specifications
Key features:
- Utilizes machine learning tools like RFdiffusion, ProteinMPNN, and AlphaFold2 for protein design and structure prediction.
- Incorporates specific peptide sequence motifs for enhanced biodegradability.
- Based on reliable covalent conjugation techniques such as SpyTag:SpyCatcher and DogTag:DogCatcher systems.
- Capable of forming fully covalently linked protein networks with tunable barrier properties.
Applications:
- Moisture barrier films for packaging and protective coatings.
- Potential use in medical or environmental applications where biodegradability is essential.
Technology readiness level
This technology is at TRL 3, having undergone experimental proof of concept. The next phase involves optimizing film assembly and testing mechanical robustness and moisture barrier properties through industry-standard assays.
About Colorado State University
Colorado State University is a comprehensive public land‑grant research university with an applied, partnership‑driven culture. Multiple research campuses—including the Fort Collins main campus, a public‑facing Denver site, and a foothills research complex with shared core facilities and pilot‑scale testbeds—enable companies to co‑locate, access instrumentation, and run validation studies. A statewide Extension network and proximity to the Front Range innovation corridor provide streamlined engagement with regional and national industry, while an integrated veterinary teaching hospital supports translational studies. Research is supported by competitive federal funding from agencies such as NSF, NIH, USDA, DOE, and DoD. A dedicated technology transfer office streamlines IP, contracting, and startup formation, with incubator and collaboration space for industry partners.
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