Crispr-guided optimization of flowering time in brassica napus via FLC allele editing
This solution uses CRISPR technology to precisely edit FLOWERING LOCUS C (FLC) alleles in Brassica napus to tune flowering time for specific climates and improve climate robustness. By disrupting selected FLC copies and alleles, it can reduce FLC-mediated delays. The approach can be integrated with editing of FT binding sites and modulation of miR156 to coordinate flowering and plant architecture for improved yield and adaptability.
Overview
This solution leverages CRISPR technology to precisely edit FLOWERING LOCUS C (FLC) alleles in Brassica napus, aiming to optimize flowering times for specific climatic conditions or to enhance climate robustness. FLC is known to delay flowering, and targeting specific copies and alleles can tune flowering across different Brassica cultivars. The strategy can be integrated with genetic editing of FT binding sites and modulation of miR156 to support both optimal flowering and improved plant architecture, with the goal of enhancing crop yield and adaptability.
Technical specifications
- Target genes: FLOWERING LOCUS C (FLC), FT, miR156
- Method: CRISPR-guided disruption of specific FLC alleles
- Applications: Adaptation of flowering time to climate, improved crop yield
- Research basis: Extensive data on FLC allele behavior in Brassica napus and related species
- Integration: Potential to combine with FT and miR156 pathways for comprehensive flowering and architecture control
Technology readiness level
This technology is currently at Technology Readiness Level 4, indicating laboratory validation. Future validation plans include germplasm modification, sequencing, and testing under controlled and field conditions to support further development and field evaluation of GE-edited plants.
About Durham University
Durham University is a collegiate public research university in North East England with a global research profile and a highly selective student body. Companies engage through shared-use laboratories, sponsored research, consultancy, and Knowledge Transfer Partnerships that embed talent within partner sites. The university maintains close ties to a regional science and technology park and national innovation assets, giving partners practical routes from proof-of-concept to scale-up. Research is supported by competitive funding from UK Research and Innovation councils, Innovate UK, and major UK charities. A dedicated technology transfer office manages IP, licensing, and spin-out creation, with entrepreneurship support and investor connections to accelerate commercialization.
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