Differential spectroscopy sensor for chloramine detection in water systems
A spectroscopic detection technology that uses differential and derivative spectroscopy to identify and quantify chloramine and other chlorine-based disinfectants in water at concentrations below standard detection limits. Designed for integration with miniature optical sensors, with initial applications in dialysis water systems.
Overview
This technology leverages differential and derivative spectroscopy to detect and quantify chloramine and other chlorine-based disinfectants in water. While the absorbance intensity of these disinfectants is inherently low, the approach separates their characteristic spectroscopic signatures from those of the surrounding water matrix. This enables accurate detection at concentrations below conventional limits, addressing a critical need in water quality monitoring for healthcare, municipal, and industrial applications. The initial target application is dialysis water systems, where precise chloramine monitoring is essential for patient safety.
Technical specifications
- Core method: Differential and derivative spectroscopy applied to UV-Vis absorbance spectra of chloramine and related chlorine-based disinfectants
- Sensitivity enhancement: Mathematical separation of target compound signatures from matrix interference, enabling detection below standard absorbance-based limits
- Sensor design: Multi-wavelength optical configuration selected for use with a miniature optical sensor platform
- Validation parameters: Detection limits, sensitivity, and robustness across the target chloramine concentration range
- Application scope: Extends to monitoring disinfection by-products and quantifying disinfection processes in water treatment
Technology readiness level
The underlying differential spectroscopy methodology has been extensively validated through numerous peer-reviewed publications on disinfection by-product formation and chloramine quantification in water. The technology is currently at an early-to-mid stage of development specific to its sensor application. Future validation will include detailed studies of differential and derivative spectra in dialysis and related water systems, generation of multi-wavelength analytical data including detection limits and sensitivity, selection of optimal wavelength sets for a miniature optical sensor, and robustness testing of the overall approach.
About University of Washington
The University of Washington is a large public research university with campuses in Seattle, Bothell, and Tacoma, known for a broad portfolio from fundamental discovery to applied innovation. Industry partners engage through a South Lake Union research campus adjacent to a major life sciences district and through collaboration programs that place faculty and students alongside corporate R&D. The university’s integration with a major academic health system enables clinical translation and large-scale trials. Research is supported by competitive federal funding from NIH, NSF, DOE, and DoD. A dedicated technology transfer office manages IP, licensing, and startup incubation with prototyping resources.
delivered to your inbox.