Dissolving microneedles for enhanced minoxidil solubilization and hair growth

Overview

This technology utilizes dissolving microneedles made from a natural compound to enhance the solubilization and delivery of minoxidil, a common hair growth stimulant. By forming micelles in water, these microneedles enable high concentrations of minoxidil to be delivered directly to hair follicles, improving effectiveness and reducing the time required for visible hair growth results. Additionally, the compound itself has vasodilatory properties, potentially enhancing blood circulation and further promoting hair health.

Technical specifications

• Microneedle Composition: Made from a natural compound that forms solid dispersions and micelles.
• Minoxidil Solubilization: Achieves solubilization of minoxidil up to ~50 mg/mL in water.
• Targeted Delivery: Microneedles facilitate direct delivery to hair follicles, enhancing absorption and effectiveness.
• Vasodilatory Effects: The compound may improve blood circulation, supporting hair growth.

Technology readiness level

The technology is currently at TRL 3, having been validated in a mouse model for androgenic alopecia. Future validation includes developing a suitable human beard regeneration model to further test efficacy, with a proposed study duration of approximately one year.