Diversified alkaloid-derived compound library for drug discovery screening
A unique compound library derived from synthetically manipulated indole alkaloids with high stereochemical complexity. Designed for target-based and phenotypic drug discovery screens to identify novel biological activities across diverse therapeutic areas.
Overview
This offering provides access to a unique compound library built from synthetically manipulated indole alkaloids with significantly different molecular architectures. The library features high stereochemical complexity designed to maximize chemical diversity for small molecule discovery. By re-engineering the biological activity of indole alkaloids, the collection aims to uncover significant activities in new areas of biology and disease. It is suitable for both target-based and phenotypic screening campaigns across a broad range of therapeutic applications.
Technical specifications
- Source material: Derived from several available alkaloid materials serving as starting points for synthetic diversification
- Synthetic approach: Synthetic organic chemistry methods used to re-engineer molecular architectures
- Stereochemical complexity: Compounds feature significantly different molecular architectures with high stereochemical complexity
- Library design: Maximally diverse small molecules generated to expand chemical space explored in screening campaigns
- Screening compatibility: Suitable for both target-based and phenotypic-based discovery screens
- Biological rationale: Built on the foundation of indole alkaloids, a privileged scaffold class with established relevance in medicinal chemistry
Technology readiness level
The compound library has been developed through synthetic organic chemistry efforts at the University of Florida and is available for screening collaborations and evaluation. The library is positioned for use in drug discovery screening programs seeking novel chemical entities with unique structural features derived from alkaloid scaffolds.
About University of Florida
The University of Florida is a comprehensive public research university with a broad academic and research portfolio and a statewide presence. Industry collaborates through co-located labs and shared core facilities and through an integrated academic health system that accelerates clinical translation. A statewide extension network and multiple research and education sites connect companies with field-scale testing and rapid deployment, while incubators and an adjacent innovation district provide pathways from lab to market. Research is supported by competitive funding from major federal agencies such as NIH, NSF, USDA, and DOE. A dedicated technology transfer office supports IP, licensing, and startup formation.
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