DNA nanoswitch technology for direct, enzyme-free genotyping
A novel DNA nanotechnology platform offering direct enzyme-free genotyping via DNA nanoswitches. This solution provides a cost-effective, rapid, and equipment-free method for detecting SNPs and biomarkers, suitable for low-resource settings.
Overview
This innovative DNA nanotechnology platform leverages engineered DNA nanoswitches to offer a direct, enzyme-free genotyping solution. Unlike traditional methods that rely on costly enzymes and high-end equipment, this technology provides a low-cost and adaptable approach. The nanoswitches can detect genetic mutations and biomarkers in complex fluids such as serum and saliva, delivering results in as little as 15 minutes. This makes it particularly suitable for low-resource environments and point-of-care applications.
Technical specifications
- Nanoswitch Design: DNA nanoswitches change conformation upon binding to specific DNA/RNA sequences, enabling direct detection.
- Detection Method: Results are read through electrophoresis, a simple and cost-effective technique.
- Target Flexibility: Easily adaptable to new genomic targets without requiring complex re-engineering.
- Applications: Effective for detecting single nucleotide polymorphisms (SNPs), gene fragments, and biomarkers in biofluids.
- Robustness: Future plans include optimizing nanoswitch design to ensure durability in biological samples like saliva.
Technology readiness level
Currently at TRL 5, the technology has demonstrated functionality in a laboratory setting. Ongoing work focuses on integrating and validating the complete workflow for end-to-end detection from genomic DNA, with plans to optimize for home environment applications.
About University at Albany, State University of New York
The University at Albany, State University of New York, is a comprehensive public research university in New York’s Capital Region with a strong orientation toward applied, partner‑driven work. ETEC, a 246,000‑sq‑ft research and innovation hub, co‑locates researchers, entrepreneurs and the UAlbany Innovation Center to accelerate translation with industry. UAlbany manages Innovate 518 and sits adjacent to the Albany NanoTech complex, whose facilities serve the University’s College of Nanotechnology, Science & Engineering—linking campus talent to a leading semiconductor ecosystem. A regional partnership with the Albany Med Health System broadens pipelines for clinical collaboration and workforce development. Research is supported by competitive federal funding alongside New York State and industry partnerships. A dedicated technology transfer office, supported by the Research Foundation for SUNY, provides IP, licensing and startup services, including SBIR/STTR guidance.
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